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Papers of the Week

2022 Oct 12

Int J Cardiol

Closed loop stimulation in patients with chronic heart failure and severe chronotropic incompetence: Responders versus non-responders.


Proff J, Merkely B, Papp R, Lenz C, Nordbeck P, Butter C, Meyerhoefer J, Doering M, MacCarter D, Ingel K, Wolfarth B, Thouet T, Landmesser U, Roser M
Int J Cardiol. 2022 Oct 12.
PMID: 36243181.


Clinical effects of rate-adaptive pacing (RAP) are unpredictable and highly variable among cardiac resynchronization therapy (CRT) patients with chronotropic incompetence. Physiologic sensors such as Closed Loop Stimulation (CLS), measuring intracardiac impedance changes (surrogate for ventricular contractility), may add clinical benefit and help identify predictors of response to RAP. The objective of the present BIOlCREATE study subanalysis was to identify criteria for selection of CRT patients who are likely to respond positively to CLS-based RAP.