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Papers of the Week


2022 Nov


Neurogastroenterol Motil


34


11

Long-lasting visceral hypersensitivity in a model of DSS-induced colitis in rats.

Authors

López-Estévez S, López-Torrellardona J M, Parera M, Martínez V
Neurogastroenterol Motil. 2022 Nov; 34(11):e14441.
PMID: 36239298.

Abstract

Persistent visceral hypersensitivity is a key component of functional and inflammatory gastrointestinal diseases. Current animal models fail to fully reproduce the characteristics of visceral pain in humans, particularly as it relates to persistent hypersensitivity. This work explores the validity of DSS-induced colitis in rats as a model to mimic chronic intestinal hypersensitivity.