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Papers of the Week

Papers: 15 Oct 2022 - 21 Oct 2022

2022 Oct 11

Biochem Pharmacol

Dexmedetomidine alleviates anxiety-like behavior in mice following peripheral nerve injury by reducing thehyperactivity of glutamatergic neurons in the anterior cingulate cortex.


Gao W, Long D-D, Pan T-T, Hu R, Chen D-Y, Mao Y, Chai X-Q, Jin Y, Zhang Z, Wang DI
Biochem Pharmacol. 2022 Oct 11:115293.
PMID: 36241093.


Treatment of chronic pain is challenged by concurrent anxiety symptoms. Dexmedetomidine is known to produce sedation, analgesia, and anxiolysis. However, the neural mechanism of dexmedetomidine-elicited anxiolysis remains elusive. Here, we aimed to test the hypothesis that the anterior cingulate cortex might be involved in dexmedetomidine-induced anxiolysis in pain.