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Papers: 8 Oct 2022 - 14 Oct 2022

2022 Oct 12

BMC Neurol



Post-fracture serum cytokine levels are not associated with a later diagnosis of complex regional pain syndrome: a case-control study nested in a prospective cohort study.


Parkitny L, McAuley JH, Herbert RD, Di Pietro F, Cashin AG, Ferraro MC, Moseley LG
BMC Neurol. 2022 Oct 12; 22(1):385.
PMID: 36224537.


Complex Regional Pain Syndrome (CRPS) is a disabling pain disorder that is most common after a distal limb fracture. While the acute systemic immune response to the injury is thought to play a role in the development of CRPS, this hypothesis has never been tested directly. Thus, we evaluated whether elevated levels of circulating pro-inflammatory cytokines early after a fracture were associated with the development of CRPS.