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Papers of the Week


Papers: 8 Oct 2022 - 14 Oct 2022


2022 Oct 12


J Orthop Surg Res


17


1

Establishment of a bipedal rat model of lumbar facet joint osteoarthritis using intraarticular injection of urinary plasminogen activator.

Authors

Yang D, Hu W, Li H, Shao Y-C, Shan J-C, Xiong X, Shuang F
J Orthop Surg Res. 2022 Oct 12; 17(1):447.
PMID: 36224572.

Abstract

Previous studies have demonstrated that by injecting uPA into the lumbar facet joints (LFJ) of normal rats, a rat LFJOA animal model can be successfully established. However, there is no evidence that intraarticular injection of uPA can induce or much serious osteoarthritis in bipedal rats, which biomechanics is much more similar to human than normal rats. To investigate whether intraarticular injection of urinary plasminogen activator (uPA) can induce LFJOA and low back pain symptoms in bipedal rats.