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Papers of the Week

Papers: 8 Oct 2022 - 14 Oct 2022

Animal Studies

2022 Oct 10

J Neuroinflammation



SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain.


Wedel S, Mathoor P, Rauh O, Heymann T, Ciotu CI, Fuhrmann DC, Fischer M J, Weigert A, Debruin N, Hausch F, Geisslinger G, Sisignano M
J Neuroinflammation. 2022 Oct 10; 19(1):254.
PMID: 36217203.


Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options are still limited because of low efficacy and sometimes severe side effects. Recently, the deficiency of FKBP51 was shown to relieve chronic pain, revealing FKBP51 as a potential therapeutic target. However, a specific and potent FKBP51 inhibitor was not available until recently which hampered targeting of FKBP51.