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Papers of the Week

2022 Oct 08

Eur J Med Res



HaNDL syndrome: a reversible cerebral vasoconstriction triggered by an infection? A case report and a case-based review.


Fiamingo G, Canavero I, Gastaldi M, Coloberti E, Buongarzone G, Ghiotto N, Bacila A, Costa A, Ravaglia S
Eur J Med Res. 2022 Oct 08; 27(1):196.
PMID: 36209134.


The syndrome of transient Headache and Neurological Deficits with cerebrospinal fluid (CSF) Lymphocytosis (HaNDL) is classified among secondary headaches attributed to "non-infectious, inflammatory intracranial disease". Despite its classification among secondary headaches, the current definition of HaNDL does not contemplate a causal agent. Thus, the aetiology, as well as the pathogenesis of both the headache and the transient focal deficits, remains unknown.