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Papers of the Week

2022 Oct 07

Eur J Drug Metab Pharmacokinet

Population Pharmacokinetics and Dosing Simulations of Intravenous Oxycodone for Perioperative Pain Relief in Adult Surgical Patients with Obesity.


Chaw S H, Lo Y L, Yeap L L, Haron D E B M, Shariffuddin I I
Eur J Drug Metab Pharmacokinet. 2022 Oct 07.
PMID: 36207565.


Oxycodone, a semisynthetic thebaine derivative µ-opioid (MOP) receptor agonist, is effective for treating moderate and severe pain in different clinical conditions. The pharmacokinetics of intravenous oxycodone in the obese population has not been studied. This study aims to characterize the pharmacokinetic profile of oxycodone after intravenous administration and to simulate an appropriate dosage for analgesic efficacy in obese patients.