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Papers of the Week


2022 Feb


J Orthop Case Rep


12


2

Approach to Total Hip Arthroplasty in Gauchers Disease with Pre-Existing Spinopelvic Fusion.

Authors

Vinay DJ, Chokkalingam S
J Orthop Case Rep. 2022 Feb; 12(2):76-80.
PMID: 36199716.

Abstract

Avascular necrosis of femoral head secondary to rare metabolic Gaucher's disease (GD) can cause debilitating hip arthritis in young adults. It is an autosomal recessive disorder caused due to deficiency of lysosome enzyme glucocerebrosidase resulting in accumulation of its substrate in macrophages. The activated macrophages or the Gaucher cells causes hepatosplenomegaly, anemia, and thrombocytopenia. Extensive marrow involvement causes bony deformity, necrosis, and pathological fractures in non-neuropathic GD. Total hip replacement (THR) for young adult with secondary arthritis due to avascular necrosis (AVN) of femoral head in GD is complex and has high failure rate. As the abnormal cell infiltration involves both femoral head and the acetabulum. It becomes even more challenging, when associated spinopelvic fusion preexists. The altered biomechanics needs special attention to the anteversion of the cup placement and deciding the combined ante-version angle (CAVA).