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Papers of the Week


Papers: 1 Oct 2022 - 7 Oct 2022


2022 Oct 05


Expert Rev Clin Pharmacol

A novel long-acting local anesthetic – HTX-011 (ZYNRELEF™) for postoperative pain control.

Authors

Kang RS, Jin Z, Gan TJ
Expert Rev Clin Pharmacol. 2022 Oct 05.
PMID: 36199229.

Abstract

Pain following most surgical procedures is expected. However, the treatment and management of postoperative surgical pain has remained challenging. The use of opioid therapy has increasingly become controversial given the limited therapeutic window of these drugs, the adverse side effects, and the potential for abuse. A multimodal approach to the treatment of postoperative pain has been shown to improve pain outcomes after surgery and improve patient satisfaction. Here, we examine a new formulation of bupivacaine and meloxicam extended-release solution HTX-011 (Zenrelef®), and its efficacy in postoperative pain control.