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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Analgesic Effectiveness and Dorsal Root Ganglia Protein Modulation of a Peripheral Adenosine Monophosphate Kinase Alpha Activator (O304) Following Lumbar Disk Puncture in the Mouse.

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Papers: 1 Oct 2022 - 7 Oct 2022


Animal Studies, Pharmacology/Drug Development


2022 Oct 06


Anesth Analg


http://www.ncbi.nlm.nih.gov/pubmed/36201356?dopt=Abstract

Analgesic Effectiveness and Dorsal Root Ganglia Protein Modulation of a Peripheral Adenosine Monophosphate Kinase Alpha Activator (O304) Following Lumbar Disk Puncture in the Mouse.

Authors

Analgesic Effectiveness and Dorsal Root Ganglia Protein Modulation of a Peripheral Adenosine Monophosphate Kinase Alpha Activator (O304) Following Lumbar Disk Puncture in the Mouse.
Das V, Basovich MB, Kroin JS, Buvanendran A, McCarthy RJ
Anesth Analg. 2022 Oct 06.
PMID: 36201356.

Abstract

Disk herniation is a primary cause of radicular back pain. The purpose of this study was to evaluate the antiallodynic effective dose in 50% of the sample (ED50) and dorsal root ganglion (DRG) protein modulation of a peripheral direct adenosine monophosphate kinase alpha (AMPKα) activator (O304) in a murine model of lumbar disk puncture.
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