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Papers of the Week

Papers: 1 Oct 2022 - 7 Oct 2022

Pharmacology/Drug Development

2022 Nov

J Orthop Translat


Intradiscal injection of human recombinant BMP-4 does not reverse intervertebral disc degeneration induced by nuclectomy in sheep.


Du J, Garcia JP, Bach FC, Tellegen AR, Grad S, Li Z, Castelein RM, Meij BP, Tryfonidou MA, Creemers LB
J Orthop Translat. 2022 Nov; 37:23-36.
PMID: 36196149.


Intervertebral disc (IVD) degeneration is suggested as a major cause of chronic low back pain (LBP). Intradiscal delivery of growth factors has been proposed as a promising strategy for IVD repair and regeneration. Previously, BMP-4 was shown to be more potent in promoting extracellular matrix (ECM) production than other BMPs and TGF-β in human nucleus pulposus (NP) cells, suggesting its applicability for disc regeneration.