I am a
Home I AM A Search Login

Papers of the Week

Papers: 1 Oct 2022 - 7 Oct 2022

Pharmacology/Drug Development

2022 Sep 23

Medicine (Baltimore)



The efficacy of parecoxib in improving pain after total knee or total hip arthroplasty: Systematic review and meta-analysis.


Hong C, Xie H-Y, Ge W-K, Yu M, Lin S-N, Liu C-J
Medicine (Baltimore). 2022 Sep 23; 101(38):e30748.
PMID: 36197263.


The cyclooxygenase-2 (COX-2) selective inhibitor parecoxib is widely used in the treatment of pain and inflammation. Parecoxib has been adopted for use for postoperative analgesia following a range of surgical procedures (orthopedic, general, gynecological, and dental surgery). Total knee or total hip arthroplasty (THA) surgery is mostly done in older patients, so postoperative analgesics need to be used more carefully, and the safety and efficacy of parecoxib in this type of surgery need to be further verified. The aim of this study was to investigate the effects of parecoxib on patient safety, cumulative morphine consumption and was at 24 and 48 hours in the analgesic treatment of total knee or THA for meta-analysis and systematic review, with few studies in this area so far.