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Papers of the Week

2022 Sep

Health Sci Rep



Low volume polyethylene glycol combined with senna versus high volume polyethylene glycol, which regimen is better for bowel preparation for colonoscopy? A randomized, controlled, and single-blinded trial.


Sadeghi A, Rahmani K, Ketabi Moghadam P, Abdi S, Jahanian A, Fathy M, Mohammadi M, Mahdavi Roshan M, Olfatifar M, Zali M R, Hatamnejad M R, Rajabnia M
Health Sci Rep. 2022 Sep; 5(5):e829.
PMID: 36172298.


Bowel preparation affects the quality of colonoscopy. Reaching the optimal preparation has been a challenge for years. Polyethylene glycol (PEG) is the sole FDA-approved substance for this purpose. However, patients find it unpleasant and often complain about its adverse effects. In this study, we aimed to reduce these complaints by lowering the amount of PEG and adding senna which is an herbal stimulant laxative.