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Papers of the Week

Papers: 1 Oct 2022 - 7 Oct 2022

Pharmacology/Drug Development

2022 Oct 01

Korean J Pain



Medial prefrontal cortex nitric oxide modulates neuropathic pain behavior through mu opioid receptors in rats.


Raisian D, Erfanparast A, Tamaddonfard E, Soltanalinejad-Taghiabad F
Korean J Pain. 2022 Oct 01; 35(4):413-422.
PMID: 36175340.


The neocortex, including the medial prefrontal cortex (mPFC), contains many neurons expressing nitric oxide synthase (NOS). In addition, increasing evidence shows that the nitric oxide (NO) and opioid systems interact in the brain. However, there have been no studies on the interaction of the opioid and NO systems in the mPFC. The objective of this study was to investigate the effects of administrating L-arginine (L-Arg, a precursor of NO) and N(gamma)-nitro-L-arginine methyl ester (L-NAME, an inhibitor of NOS) into the mPFC for neuropathic pain in rats. Also, we used selective opioid receptor antagonists to clarify the possible participation of the opioid mechanism.