I am a
Home I AM A Search Login

Papers of the Week

Papers: 1 Oct 2022 - 7 Oct 2022

Animal Studies, Human Studies


2022 Sep 30

J Headache Pain



Exploring the neurobiology of the premonitory phase of migraine preclinically – a role for hypothalamic kappa opioid receptors?


Kopruszinski CM, Vizin R, Watanabe M, Martinez AL, de Souza L H M, Dodick DW, Porreca F, Navratilova E
J Headache Pain. 2022 Sep 30; 23(1):126.
PMID: 36175828.


The migraine premonitory phase is characterized in part by increased thirst, urination and yawning. Imaging studies show that the hypothalamus is activated in the premonitory phase. Stress is a well know migraine initiation factor which was demonstrated to engage dynorphin/kappa opioid receptors (KOR) signaling in several brain regions, including the hypothalamus. This study proposes the exploration of the possible link between hypothalamic KOR and migraine premonitory symptoms in rodent models.