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Papers of the Week

Papers: 24 Sep 2022 - 30 Sep 2022

Human Studies

2022 Sep 22

Comput Biol Med


Identification of key candidate genes and biological pathways in neuropathic pain.


Cui C-Y, Liu X, Peng M-H, Liu Q, Zhang Y
Comput Biol Med. 2022 Sep 22; 150:106135.
PMID: 36166989.


Neuropathic pain is a common chronic pain, characterized by spontaneous pain and mechanical allodynia. The incidence of neuropathic pain is on the rise due to infections, higher rates of diabetes and stroke, and increased use of chemotherapy drugs in cancer patients. At present, due to its pathophysiological process and molecular mechanism remaining unclear, there is a lack of effective treatment and prevention methods in clinical practice. Now, we use bioinformatics technology to integrate and filter hub genes that may be related to the pathogenesis of neuropathic pain, and explore their possible molecular mechanism by functional annotation and pathway enrichment analysis.