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Papers of the Week

Papers: 24 Sep 2022 - 30 Sep 2022

Pharmacology/Drug Development

2022 Sep 28

Neurotox Res

Neurophysiopathological Aspects of Paclitaxel-induced Peripheral Neuropathy.


Velasco-González R, Coffeen U
Neurotox Res. 2022 Sep 28.
PMID: 36169871.


Chemotherapy is widely used as a primary treatment or adjuvant therapy for cancer. Anti-microtubule agents (such as paclitaxel and docetaxel) are used for treating many types of cancer, either alone or in combination. However, their use has negative consequences that restrict the treatment's ability to continue. The principal negative effect is the so-called chemotherapy-induced peripheral neuropathy (CIPN). CIPN is a complex ailment that depends on diversity in the mechanisms of action of the different chemotherapy drugs, which are not fully understood. In this paper, we review several neurophysiological and pathological characteristics, such as morphological changes, changes in ion channels, mitochondria and oxidative stress, cell death, changes in the immune response, and synaptic control, as well as the characteristics of neuropathic pain produced by paclitaxel.