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Papers of the Week

2022 Sep 22

BMJ Open



Clonidine as analgesia during retinopathy of prematurity screening in preterm infants (cloROP): protocol for a randomised controlled trial.


Carlsen Misic M, Eriksson M, Normann E, Pettersson M, Blomqvist Y, Olsson E
BMJ Open. 2022 Sep 22; 12(9):e064251.
PMID: 36137627.


Preterm infants are at risk of negative consequences from stress and pain at the same time as they often are in need of intensive care that includes painful interventions. One of the frequent painful procedures preterm infants undergo is eye examination screening to detect early signs of ROP (retinopathy of prematurity). These examinations are both stressful and painful, and despite a multitude of research studies, no conclusive pain-relieving treatment has been demonstrated. The main aim of this trial is to investigate the analgesic effect of clonidine during ROP eye examinations.