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Papers of the Week

2022 Sep

Infect Dis Clin North Am



Human Granulocytic Anaplasmosis.


MacQueen D, Centellas F
Infect Dis Clin North Am. 2022 Sep; 36(3):639-654.
PMID: 36116840.


Human granulocytic anaplasmosis (HGA) is a bacterial infection caused by Anaplasma phagocytophilum and transmitted by the bite of the black-legged (deer tick) in North America. Its incidence is increasing. HGA can be transmitted after 24 to 48 hours of tick attachment. The incubation period is 5 to 14 days after a tick bite. Symptoms include fever, chills, headache, and myalgia. Complications include shock, organ dysfunction, and death. Mortality is less than 1% with appropriate treatment. Doxycycline is first line treatment for all ages. Start it empirically if symptoms and risk factors suggest HGA. PCR is the confirmatory test of choice.