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Papers of the Week

2022 Sep 19

Nat Prod Res

Analgesic effects of saikosaponin A in a rat model of chronic inflammatory pain.


Lobina C, Lee J H, Pel P, Chin Y-W, Kwon H C, Colombo G
Nat Prod Res. 2022 Sep 19:1-5.
PMID: 36121752.


Saikosaponin A (SSA) is the main active ingredient of roots of the East Asian medicinal plant, L. The present study was aimed at delving into the analgesic properties of SSA in a model of chronic inflammatory pain. To this end, rats were initially treated intraplantarly with complete Freund's adjuvant for induction of hyperalgesia. Twenty-four hours later, rats were acutely treated with SSA (0, 1 and 2 mg/kg, i.p.) and exposed to the Von Frey monofilament test or Randall-Selitto paw pressure test for assessment of mechanical hyperalgesia. Treatment with 2 mg/kg SSA had analgesic effects: the nocifensive reaction (paw withdrawal) occurred later and required application of the nociceptive stimulus at a stronger pressure. The analgesic effects of SSA were of magnitude comparable to that of the effects exerted by the reference compound, acetyl salicylic acid (100 mg/kg, i.p.). The well-described anti-inflammatory properties of SSA likely underlie its analgesic effects.