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Papers of the Week


Papers: 17 Sep 2022 - 23 Sep 2022


2022 Sep 15


Cochrane Database Syst Rev


9

Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.

Authors

Candy B, Jones L, Vickerstaff V, Larkin PJ, Stone P
Cochrane Database Syst Rev. 2022 Sep 15; 9:CD006332.
PMID: 36106667.

Abstract

Opioid-induced bowel dysfunction (OIBD) is characterised by constipation, incomplete evacuation, bloating, and gastric reflux. It is one of the major adverse events (AEs) of treatment for pain in cancer and palliative care, resulting in increased morbidity and reduced quality of life. This review is a partial update of a 2008 review, and critiques as previous update (2018) trials only for people with cancer and people receiving palliative care.