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Papers of the Week

Papers: 17 Sep 2022 - 23 Sep 2022

2022 Oct 01

Clin J Pain



Exploring the Relationship Between Endogenous Pain Modulation, Pain Intensity, and Depression in Patients Using Opioids for Chronic Low Back Pain.


Lazaridou A, Paschali M, Zgierska AE, Garland EL, Edwards RR
Clin J Pain. 2022 Oct 01; 38(10):595-600.
PMID: 36108108.


Endogenous pain modulatory processes appear to play an important role in shaping pain-related outcomes, but we know relatively little about the influence of psychosocial factors on those pain modulatory processes. The primary objective of this study was to explore associations between endogenous pain modulation (ie, conditioned pain modulation, CPM; temporal summation, TS), chronic pain, and negative affective factors (ie, depression, anxiety symptoms) in a sample of participants with chronic low back pain (CLBP) treated with long-term daily opioids.