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Papers of the Week

Papers: 17 Sep 2022 - 23 Sep 2022

2022 Sep 15

Ann Rheum Dis

Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis.


Ohzono H, Hu Y, Nagira K, Kanaya H, Okubo N, Olmer M, Gotoh M, Kurakazu I, Akasaki Y, Kawata M, Chen E, Chu AC, Johnson KA, Lotz MK
Ann Rheum Dis. 2022 Sep 15.
PMID: 36109140.


Osteoarthritis (OA) features ageing-related defects in cellular homeostasis mechanisms in articular cartilage. These defects are associated with suppression of forkhead box O (FoxO) transcription factors. FoxO1 or FoxO3 deficient mice show early onset OA while FoxO1 protects against oxidative stress in chondrocytes and promotes expression of autophagy genes and the essential joint lubricant proteoglycan 4 (PRG4). The objective of this study was to identify small molecules that can increase FoxO1 expression.