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Papers of the Week

2022 Sep 01



Prim-O-glucosycimifugin attenuates liver injury in septic mice by inhibiting NLRP3 inflammasome/caspase-1 signaling cascades in macrophages.


Liu L-L, Yan X, Xue K-Y, Wang X-M, Li L-Y, Chen H-Y, Li R-L, Li H, Lan J, Xin J-J, Li X, Zhuo C-L, Wu Z, Zhang D, Huang W-J, Wang Y-L, Li X-Y, Jiang W, Zhang H-Y
Phytomedicine. 2022 Sep 01; 106:154427.
PMID: 36088791.


Liver dysfunction and liver failure are serious complications of sepsis, directly leading to septic progression and death. Now, there is no specific therapeutics available for sepsis-related liver dysfunction. Prim-O-glucosylcimifugin (POG), a chromone richest in the roots of Saposhnikovia divaricata (Turcz.) Schischk, is usually used to treat headache, rheumatoid arthritis and tetanus. While, the underlying mechanisms of POG against sepsis-induced liver damage and dysfunction are still not clear.