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Papers of the Week

2022 Sep 13

Turk J Gastroenterol

The Investigation of Therapeutic Implications of Mast Cell Stabilizer Cromolyn Sodium on Cholestasis and Cholestatic Pruritus in Experimental Cholestasis.


Yurdakul Ertan H, Özbakış Dengiz G, Barut F, Yılmaz Ürün Y, Can M, Hussen S U, Üstündağ Y
Turk J Gastroenterol. 2022 Sep 13.
PMID: 36098363.


Relevant studies have indicated that hepatic mast cells may have potential roles in the progression of cholestasis and cholestasis-induced itch. We aimed to compare the effects of cromolyn sodium and other medications on cholestatic pruritus, serum biochemistry, histamine, total bile acids, autotaxin, liver histopathology, and mast cell distribution in tissues in an experimental cholestasis model conducted by bile duct ligation.