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Papers of the Week

Papers: 10 Sep 2022 - 16 Sep 2022

Pharmacology/Drug Development

2022 Sep 09

Medicine (Baltimore)



Relative safety and efficacy of topical and oral NSAIDs in the treatment of osteoarthritis: A systematic review and meta-analysis.


Wang Y, Fan M, Wang H, You Y, Wei C, Liu M, Luo A, Xu X, Duan X
Medicine (Baltimore). 2022 Sep 09; 101(36):e30354.
PMID: 36086745.


Osteoarthritis (OA) often affects the hands, knees, and hip joints, causing considerable pain and disability, and often affecting the patient's quality of life. Non-steroidal anti-inflammatory drugs (NSAIDs) are common pain relievers often applied as first line therapies for OA. However, prolonged NSAIDs application can have unwanted side effects. Given this, this study was designed to systematically evaluate the efficacy and safety of topical and oral NSAIDs for the treatment of OA.