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Papers of the Week

2022 Sep 10

Curr Pain Headache Rep

Platelet-Rich Plasma Injections: Pharmacological and Clinical Considerations in Pain Management.


Grossen AA, Lee BJ, Shi HH, Shakir HJ, Cornett EM, Kaye AD
Curr Pain Headache Rep. 2022 Sep 10.
PMID: 36087238.


Regenerative medicine through interventional pain procedures is evolving with data demonstrating efficacy for a number of pain states in recent years. Platelet-rich plasma (PRP), defined as a sample of plasma with a platelet concentration 3 to 5 times greater than the physiologic platelet concentration found in healthy whole blood, releases bioactive proteins which can restore anatomical function in degenerative states. PRP is dense in growth factors, such as platelet-derived growth factor, transforming growth factor-beta1, basic fibroblastic growth factor, vascular endothelial growth factor, and epidermal growth factors.