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Papers of the Week

2022 Aug

Zhongguo Yi Xue Ke Xue Yuan Xue Bao



[Correlation between Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Signaling Pathway and Non-infectious Diseases].


Yu H-X, Rui H-Y, Han Z-Q, Li R-C, Liu L-L, Xue L, Chen Y-G
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Aug; 44(4):661-667.
PMID: 36065699.


As a DNA receptor in the cytoplasm,cyclic GMP-AMP synthase (cGAS) can recognize abnormal DNA in the cytoplasm and activate stimulator of interferon genes (STING) to regulate the immune response. The recent studies have demonstrated that this pathway plays a role in non-infectious inflammatory diseases by promoting the expression of type Ⅰ interferon and interferon-stimulated gene.This article reviews the activation and regulation of cGAS-STING pathway in multiple systems and the effect of this pathway on the occurrence and progression of non-infectious inflammatory diseases,providing theoretical reference for future application of cGAS-STING pathway-related drugs in non-infectious inflammatory diseases.