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Papers of the Week

Papers: 3 Sep 2022 - 9 Sep 2022

Pharmacology/Drug Development

2022 Sep 06

Mol Pain

Dimethyl Fumarate Attenuates Pain Behaviors in Osteoarthritis Rats via Induction of Nrf2-Mediated Mitochondrial Biogenesis.


Gao S-J, Li D-Y, Liu D-Q, Sun J, Zhang L-Q, Wu J-Y, Song F-H, Zhou Y-Q, Mei W
Mol Pain. 2022 Sep 06:17448069221124920.
PMID: 36065971.


Osteoarthritis (OA), a chronic degenerative disease, leads to pain and loss of function. Existing treatments for OA pain have limited efficacy and show significant side effects. Dimethyl fumarate, a robust nuclear factor erythroid 2-related factor 2 (Nrf2) activator, could alleviate pain behaviors in chronic pain. This study aims to investigate the role of dimethyl fumarate in a rat model of OA and its underlying mechanisms.