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Papers of the Week

Papers: 3 Sep 2022 - 9 Sep 2022

Pharmacology/Drug Development

2022 Aug 31

Behav Brain Res

Thermal Antinociceptive Responses to Alcohol in DBA/2 J and C57BL/6 J Inbred Male and Female Mouse Strains.


White A, Caillaud M, Carper M, Poklis J, Miles MF, Damaj IM
Behav Brain Res. 2022 Aug 31:114087.
PMID: 36057379.


The phenomenon of alcohol analgesia and tolerance can facilitate misuse and lead to the development of alcohol use disorder (AUD). Numerous alcohol-induced behaviors are genetically influenced; however, it is unknown if alcohol analgesia has a genetic contribution. Rodent studies have shown that alcohol responses differ vastly between two widely studied inbred strains of mice, C57BL/6J (B6) and DBA/2J (D2). Here, we used B6 and D2 mice as an initial behavioral genetic analysis of acute alcohol-induced antinociception.