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Papers of the Week

2022 Jul




Sildenafil-Induced Acute Fulminant Hepatic Failure: Tragedy After Triumph.


Pawar T, Saboo K, Patel M, Kumar S, Acharya S
Cureus. 2022 Jul; 14(7):e27378.
PMID: 36046329.


Sildenafil citrate is a specific phosphodiesterase type 5-enzyme blocker that can enhance the indirect impacts of nitric oxide on vascular smooth muscle and permeability via the guanosine monophosphate (c-GMP) route in the penis erectile tissue. Though the medication is well taken, particular side effects such as flushes, headache, indigestion, and retinal abnormalities have indeed been reported. Liver toxicity caused by sildenafil use is thought to be quite infrequent. There have been few studies that looked at a potential link between sildenafil usage and liver problems, and the underlying cause involved for liver toxicity is still unknown. We report a unique instance of acute severe hepatitis with fulminant hepatic failure in a 38-year-old male patient after taking sildenafil citrate.