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gy2022-1-3
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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / R399E, a mutated form of Growth and Differentiation Factor 5, for disease modification of osteoarthritis.

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Papers: 3 Sep 2022 - 9 Sep 2022


Animal Studies


2022 Sep 02


Arthritis Rheumatol


http://www.ncbi.nlm.nih.gov/pubmed/36054172?dopt=Abstract

R399E, a mutated form of Growth and Differentiation Factor 5, for disease modification of osteoarthritis.

Authors

R399E, a mutated form of Growth and Differentiation Factor 5, for disease modification of osteoarthritis.
Gigout A, Werkmann D, Menges S, Brenneis C, Henson F, Cowan KJ, Musil D, Thudium CS, Gühring H, Michaelis M, Kleinschmidt-Doerr K
Arthritis Rheumatol. 2022 Sep 02.
PMID: 36054172.

Abstract

To preclinically characterize a mutant form of growth and differentiation factor 5 (GDF5, R399E) with reduced osteogenic properties, as a potential disease-modifying osteoarthritis (OA) drug.
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