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Papers of the Week

Papers: 27 Aug 2022 - 2 Sep 2022

2022 Aug 26


Stability of Morphine Sulfate-Clonidine and Sufentanil-Clonidine Mixtures.


Sorrieul J, Robert J, Vincent L, Andre M, Bourcier B, Bienfait F, Hamon S J, Dupoiron D, Devys C
Neuromodulation. 2022 Aug 26.
PMID: 36038481.


Spinal analgesia is recommended for intractable cancer pain. Morphine-clonidine and sufentanil-clonidine are often used in association in intrathecal drug delivery systems, injected by intraabdominal pumps. To refill these pumps and to limit patient transport, it may be necessary to ship the mixtures in polypropylene syringes to peripheral establishments located near patient homes. The purpose of this study is to determine the stability of morphine-clonidine and sufentanil-clonidine mixtures in polypropylene syringes to ensure the best and safest transport conditions and in implantable pumps for intrathecal use.