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Papers of the Week
Spinal Sirtuin 3 Contributes to Electroacupuncture Analgesia in Mice with Chronic Constriction Injury-Induced Neuropathic Pain.
Abstract
Electroacupuncture (EA) is a traditional Chinese therapeutic technique that has a beneficial effect on neuropathic pain; however, the specific mechanism remains unclear. In this study, we investigated whether EA inhibits spinal Ca/calmodulin-dependent protein kinase II (CaMKIIα) phosphorylation through Sirtuin 3 (SIRT3) protein, thus relieving neuropathic pain.