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Papers of the Week

2022 Aug 26

BMC Pregnancy Childbirth



Fetal adverse effects following NSAID or metamizole exposure in the 2nd and 3rd trimester: an evaluation of the German Embryotox cohort.


Dathe K, Frank J, Padberg S, Hultzsch S, Beck E, Schaefer C
BMC Pregnancy Childbirth. 2022 Aug 26; 22(1):666.
PMID: 36028798.


Non-steroidal anti-inflammatory drugs (NSAID) are frequently used to treat pain, fever and inflammatory conditions. Due to evidenced fetotoxicity, treatment with NSAID and metamizole should be avoided in the 3rd trimester of pregnancy. There is an ongoing debate on fetotoxic risk of 2nd trimester use which is why we have conducted this study.