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Papers of the Week
Analgesic Dorsal Root Ganglion Field Stimulation Blocks Both Afferent and Efferent Spontaneous Activity in Sensory Neurons of Rats with Monosodium Iodoacetate-induced Osteoarthritis.
Abstract
Chronic joint pain is common in patients with osteoarthritis (OA). Non-steroidal anti-inflammatory drugs and opioids are used to relieve OA pain, but they are often inadequately effective. Dorsal root ganglion field stimulation (GFS) is a clinically used neuromodulation approach, although it is not commonly employed for patients with OA pain. GFS showed analgesic effectiveness in our previous study using the monosodium iodoacetate (MIA) – induced OA rat pain model. This study was to evaluate the mechanism of GFS analgesia in this model.