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Papers of the Week

Papers: 27 Aug 2022 - 2 Sep 2022


Human Studies

2022 Aug 20

J Clin Med



Gentle Touch Therapy, Pain Relief and Neuroplasticity at Baseline in Fibromyalgia Syndrome: A Randomized, Multicenter Trial with Six-Month Follow-Up.


Salgado A S I, Takemoto M H, de Souza C F T C, Salm D C, da Rosa D, Cardoso G C, Ludtke D D, Soares S F C, Ferreira J K, Dutra A R, Szeremeta Y C, Mazzardo G, Mayra J, da Sheffer D L, Caumo W, Bittencourt EB, Schleip R, Latini A, Bobinski F, Martins D F
J Clin Med. 2022 Aug 20; 11(16).
PMID: 36013137.


Fibromyalgia (FM) is considered a stress-related disorder characterized mainly by chronic widespread pain. Its pathogenesis is unknown, but cumulative evidence points at dysfunctional transmitter systems and inflammatory biomarkers that may underlie the major symptoms of the condition. This study aimed to evaluate pain scores (primary outcome), quality of life, inflammatory biomarkers and neurotransmitter systems in women with FM (secondary outcomes) subjected to gentle touch therapy (GTT) or placebo.