Percutaneous coronary interventions create stress and anxiety in patients, which usually affect blood pressure. Safe sedation is considered cornerstone therapy as relieves stress and pain. In chronic heart diseases the patient tries to negotiate the challenges of his illness which often aggravate his anxiety. The patient experiences the inability to manage and respond to others and/or his expectations, and as a result he "hurts" himself mentally. Self-compassion and self-esteem contribute to resilience. Resilience is a protective psychological factor in heart diseases.Purpose: The purpose of the research is the nursing monitoring and recording of the effects of the administered mild sedatives or analgesia during a percutaneous coronary intervention and the patients' perception of the care provided.Materials & Method: Questionnaires were used, answered by cardiac patients undergoing percutaneous coronary interventions (coronary angiography and angioplasty). The sample of participants is 100 people, where the 50 received midazolam (Dormixal) and fentanyl (Fentanyl) (group 1) five minutes before the examination and the remaining 50 did not (group 2). Blood pressure was measured and recorded before the start of the procedure, during, and at the end of it, in both groups to investigate a possible effect of the treatment.