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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Peimine suppresses collagen-induced arthritis, activated fibroblast-like synoviocytes and TNFα-induced MAPK pathways.

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2022 Aug 23


Int Immunopharmacol


http://www.ncbi.nlm.nih.gov/pubmed/36027853?dopt=Abstract


111

Peimine suppresses collagen-induced arthritis, activated fibroblast-like synoviocytes and TNFα-induced MAPK pathways.

Authors

Peimine suppresses collagen-induced arthritis, activated fibroblast-like synoviocytes and TNFα-induced MAPK pathways.
Zhou J, Mao Y, Shi X, Zhang Y, Yu X, Liu X, Diao L, Yang X, Liu C, Liu D, Tan X, Liu M
Int Immunopharmacol. 2022 Aug 23; 111:109181.
PMID: 36027853.

Abstract

Peimine (PM), a main isosterol alkaloid component isolated from the bulbs of traditional Chinese herb Fritillaria cirrhosa D. Don, has been demonstrated to exhibit multiple pharmacological properties, including anti-inflammation, anti-cancer and pain suppression. However, its effect on rheumatoid arthritis (RA) remains unknown. In the present study, we investigated the effect of PM on collagen-induced arthritis (CIA) rats in vivo and its inhibition on destructive behaviors of arthritic fibroblast-like synoviocytes (FLSs) in vitro.
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