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Papers of the Week
Sumatriptan prevents central sensitisation specifically in the trigeminal dermatome in humans.
Authors
Abstract
The exact mechanism and site of action of triptans in aborting migraine attacks remain under debate. We hypothesized that the clinical efficacy of triptans lies in aborting central sensitization and focused on the question of why triptans are headache-specific, i.e. highly effective in migraine and cluster headache and ineffective in extracephalic pain.