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Papers of the Week

Papers: 20 Aug 2022 - 26 Aug 2022

Pharmacology/Drug Development

2022 Aug 24

Eur J Pain

Sumatriptan prevents central sensitisation specifically in the trigeminal dermatome in humans.


Peng K-P, Jürgens T, Basedau H, Ortlieb L, May A
Eur J Pain. 2022 Aug 24.
PMID: 36001070.


The exact mechanism and site of action of triptans in aborting migraine attacks remain under debate. We hypothesized that the clinical efficacy of triptans lies in aborting central sensitization and focused on the question of why triptans are headache-specific, i.e. highly effective in migraine and cluster headache and ineffective in extracephalic pain.