I am a
Home I AM A Search Login

Papers of the Week

Papers: 20 Aug 2022 - 26 Aug 2022

Animal Studies, Pharmacology/Drug Development


Int J Nanomedicine


Rhodojaponin III-Loaded Chitosan Derivatives-Modified Solid Lipid Nanoparticles for Multimodal Antinociceptive Effects in vivo.


Yang Q, Yang J, Sun S, Zhao J, Liang S, Feng Y, Liu M, Zhang J
Int J Nanomedicine. 2022; 17:3633-3653.
PMID: 35996527.


Rhodojaponin III (RJ-III) is a bioactive diterpenoid, which is mainly found in G. Don (Ericaceae), a potent analgesia in traditional Chinese medicine with several years of clinical applications in the country. However, its clinical use is limited by its acute toxicity and poor pharmacokinetic profiles. To reduce such limitations, the current study incorporated RJ-III into the colloidal drug delivery system of hydroxypropyl trimethyl ammonium chloride chitosan (HACC)-modified solid lipid nanoparticles (SLNs) to improve its sustained release and antinociceptive effects in vivo for oral delivery.