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Papers of the Week
Biochemical and clinical manifestations in adults with hypophosphatasia: a national cross-sectional study.
Abstract
Hypophosphatasia (HPP) is a rare disease affecting bone mineralization. Adults with HPP have an increased occurrence of low-energy fractures, which cannot be explained by reduced bone mass assessed by dual energy X-ray absorptiometry. The bone phenotype in adults with HPP requires further studies investigating bone strength and bone structural parameters.