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Papers of the Week

Papers: 20 Aug 2022 - 26 Aug 2022

Animal Studies


2022 Aug 19

J Headache Pain



Cortical spreading depression can be triggered by sensory stimulation in primed wild type mouse brain: a mechanistic insight to migraine aura generation.


Hanalioglu S, Taskiran-Sag A, Karatas H, Donmez-Demir B, Yilmaz-Ozcan S, Eren-Kocak E, Gursoy-Ozdemir Y, Dalkara T
J Headache Pain. 2022 Aug 19; 23(1):107.
PMID: 35986251.


Unlike the spontaneously appearing aura in migraineurs, experimentally, cortical spreading depression (CSD), the neurophysiological correlate of aura is induced by non-physiological stimuli. Consequently, neural mechanisms involved in spontaneous CSD generation, which may provide insight into how migraine starts in an otherwise healthy brain, remain largely unclear. We hypothesized that CSD can be physiologically induced by sensory stimulation in primed mouse brain.