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Papers of the Week

2022 Aug 21

Acta Anaesthesiol Scand

Risks of serious adverse events associated with non-steroidal anti-inflammatory drugs in gastrointestinal surgery. A protocol for a systematic review with meta-analysis and trial sequential analysis.


Bukhari S, Leth M F, Laursen C C W, Larsen M, Tornøe A S, Jakobsen JC, Maagaard M, Mathiesen O
Acta Anaesthesiol Scand. 2022 Aug 21.
PMID: 35989476.


Postoperative pain is frequent following gastrointestinal surgery and may result in prolonged hospitalisation, delayed recovery, and lower quality of life. Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics and recommended by Enhanced Recovery After Surgery guidelines as part of opioid-sparing multimodal treatment. However, perioperative NSAID treatment may be associated with increased risk of harm. We will investigate the risks of serious adverse events associated with perioperative NSAID treatment in patients undergoing gastrointestinal surgery.