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Papers of the Week

2022 Aug

J Dent Anesth Pain Med



Dexmedetomidine and LPS co-treatment attenuates inflammatory response on WISH cells via inhibition of p38/NF-κB signaling pathway.


Kim T-S, Yoon J-Y, Kim C-H, Choi E-J, Kim Y H, Kim E-J
J Dent Anesth Pain Med. 2022 Aug; 22(4):277-287.
PMID: 35991362.


Inflammatory dental diseases that occur during pregnancy can cause preterm labor and/or intrauterine growth restriction. Therefore, proactive treatment of dental diseases is necessary during pregnancy. Dexmedetomidine (DEX) is a widely used sedative in the dental field, but research on the effect of DEX on pregnancy is currently insufficient. In this study, we investigated the effects of co-treatment with DEX and lipopolysaccharide (LPS) on inflammatory responses in human amnion-derived WISH cells.