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Papers of the Week

2022 Oct

Radiol Case Rep



A rare case of sphenoid giant cell tumor: Case report & review of imaging features post short-term denosumab treatment.


Aassouani F, El Bouardi N, Charifi Y, Maadin K, Bouziane A, Haloua M, Alaoui Lamrani M Y, Arifi S, Bouhafa T, Boubbou M, Maaroufi M, Alami B
Radiol Case Rep. 2022 Oct; 17(10):3830-3834.
PMID: 35982722.


Giant cell tumors (GCTs) are locally aggressive but rarely malignant bone neoplasms that uncommonly involve the skull. In this report, we describe a tumor of the sphenoid sinus. A 51-year-old female was presented with headache, and bilateral decreased visual acuity, CT scan, and brain MRI revealed an infra-sellar enhancing tumor expanding to the sellar and supra-sellar region which proved to be a GCT. the patient had received 03 months of preoperative denosumab-based treatment and imaging follow-up showed regression in size and morphology modifications of tumor tissue. : This is one of few reports to describe the appearance of sphenoid bone GCT, and the first report to highlight the effects of short-term denosumab treatment in GCTb in such a location.