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Papers of the Week

2022 Aug

Drugs Today (Barc)



Atogepant for migraine.


Bedrin K, Ailani J
Drugs Today (Barc). 2022 Aug; 58(8):399-405.
PMID: 35983926.


Atogepant is a selective oral, small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist that has been approved for preventive treatment of migraine. CGRP is a neuropeptide involved in vasodilation and cerebrovascular regulation. CGRP is the most potent vasoactive constituent of the cerebrovascular trigeminal neuronal system and has a key role in migraine. Medications targeting CGRP are being used as migraine preventive and abortive treatments.