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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain.

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Papers: 13 Aug 2022 - 19 Aug 2022

RESEARCH TYPE:
Psychology


Animal Studies, Pharmacology/Drug Development


2022 Aug 16


J Headache Pain


http://www.ncbi.nlm.nih.gov/pubmed/35974316?dopt=Abstract


23


1

HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain.

Authors

HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain.
Du Y, Xu C-L, Yu J, Liu K, Lin S-D, Hu T-T, Qu F-H, Guo F, Lou G-D, Nishibori M, Hu W-W, Chen Z, Zhang S-H
J Headache Pain. 2022 Aug 16; 23(1):102.
PMID: 35974316.

Abstract

Whether neuroinflammation causes comorbid mood disorders in neuropathic pain remains elusive. Here we investigated the role of high mobility group box 1 protein (HMGB1), a proinflammatory cytokine, in the medial prefrontal cortex (mPFC) in anxiety comorbidity of neuropathic pain.
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