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Papers of the Week

2022 Aug 16

Am J Respir Crit Care Med

An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE): A Phase Ib/IIa Randomised Controlled Trial.


Gaughan EE, Quinn TM, Mills A, Bruce AM, Antonelli J, MacKinnon A, Aslanis V, Li F, O'Connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Gwyer Findlay E, Parker RA, et al.
Am J Respir Crit Care Med. 2022 Aug 16.
PMID: 35972987.


High circulating galectin-3 is associated with poor outcomes in patients with COVID-19. We hypothesised that GB0139, a potent inhaled thiodigalactoside galectin-3 inhibitor with anti-inflammatory and antifibrotic actions, would be safely and effectively delivered in COVID-19 pneumonitis.