I am a
Home I AM A Search Login

Papers of the Week


2022 Aug 16


Am J Respir Crit Care Med

An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE): A Phase Ib/IIa Randomised Controlled Trial.

Authors

Gaughan EE, Quinn TM, Mills A, Bruce AM, Antonelli J, MacKinnon A, Aslanis V, Li F, O'Connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Gwyer Findlay E, Parker RA, et al.
Am J Respir Crit Care Med. 2022 Aug 16.
PMID: 35972987.

Abstract

High circulating galectin-3 is associated with poor outcomes in patients with COVID-19. We hypothesised that GB0139, a potent inhaled thiodigalactoside galectin-3 inhibitor with anti-inflammatory and antifibrotic actions, would be safely and effectively delivered in COVID-19 pneumonitis.